One temporary fellow position is available in the Laboratory of Genome Integrity at the European Institute of Oncology (Milan, Italy) led by Prof. Stefano Santaguida. Our lab is interested in understanding the process of chromosome segregation and in studying how errors in this process are affecting cell physiology. We welcome graduate students with an interest in cell biology, molecular biology, medicine and cancer biology, that are excited to study the consequences of changes in chromosome number on cellular functions.
Over the duration of the temporary fellowship, the student will work on understanding the contribution of genomic instability in tumorigenesis. S/he will take advantage of an interdisciplinary approach that combines confocal microscopy, next generation sequencing (RNA-seq and Single Cell DNA sequencing) and CRISPR/Cas9-mediated genome editing.
- Master Degree in life sciences or related disciplines
- Strong interest in chromosome segregation, cell cycle and cancer biology
- Technical expertise with molecular biology, cell biology (e.g., immunofluorescence, flow cytometry, time-lapse microscopy) and cell culture techniques
- Able to work both independently and as part of a laboratory team
The position will be immediately available and will end on September 2024. Post-graduate students will be encouraged to apply at the selection of the European School of Molecular Medicine SEMM (www.semm.it) in July 2024 to join our PhD Programme.
Find more about the work of the Santaguida Lab at www.santaguidalab.org
To apply, please send a cover letter describing your research experience and interests, CV and references to [email protected]
Recent selected publications:
- Garribba L, De Feudis G, et al and Santaguida S, Short-term molecular consequences of chromosome mis-segregation for genome stability, Nature Communications 2023
- Garribba L, Santaguida S, The Dynamic Instability of the Aneuploid Genome, Front Cell Dev Biol. 2022
- Ippolito MR, et al and Santaguida S, Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy, Developmental Cell, 2021
- Wang RW, et al and Santaguida S, Aneuploid senescent cells activate NF-kB to promote their immune clearance, EMBO Reports, 2021
- Martin S, Santaguida S, Understanding Complexity of Cancer Genomes: Lessons from Errors, Developmental Cell 2020
Posted on 12th September 2023