The lab of Epigenetic Mechanisms in Cancer headed by Prof. Diego Pasini is looking for a highly motivated scientist with a degree in a life science/computational discipline and previous experience in computational science interested to work on cancer-related molecular mechanisms that links chromatin remodeling and modifications with the control of transcriptional identity in the regulation of stem cell activity, regeneration and oncogenesis using bioinformatic approaches on multi-omics data.
The Pasini’s lab is based at the Department of Experimental Oncology within the IRCCS European Institute of Oncology, one of Europe’s most influential cancer research institutes. As part of the IEO, we benefit from a highly competitive, international and scientifically stimulating environment that offer excellent working conditions, state-of-the-art facilities and infrastructures including a large community of computational scientists (>50) in which the applicant will be fully embedded and integrated (www.research.ieo.it). The labs are located within the metropolitan area of Milan close to the city center (~3 km) which provides several international opportunities and stimulating off-work activities.
Qualifications: Applicants should hold a degree in a life/computational science discipline and previous experience with bioinformatic approaches applied to molecular and cellular biological questions.
Key requirements: Knowledge with R-programming and Linux environment, proficient English, independent working capacity in line with career stage, excellent organizational and collaborative skills. Candidates are expected to be self-motivated research scientists driven by scientific curiosity and proactive in developing their research projects.
Ph.D. training: Post-graduate applicants will have the possibility and will be encouraged to apply to the selection (September 2023) of the European School of Molecular Medicine SEMM (www.semm.it) to join our Ph.D. program in Molecular Medicine.
The institution: The European Institute of Oncology (IEO) is one of the leading research institutes in Italy. IEO operates as a Comprehensive Cancer Center, linking fundamental and applied research to clinical activities, patient care and clinical trials. The Department of Experimental Oncology (DEO) hosts ~250 scientists working in 20 independent research groups and units. DEO is located within a scientific campus together with two other partner institutions: the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT). The IEO is one of the 13 members of the EU-LIFE alliance to promote excellence in life sciences in Europe. IEO is an equal opportunity employer committed to excellence through diversity.
Salary: A competitive salary will be offered depending on experience and qualifications.
Deadline: All applications should be submitted by the end of January 2023
- Conway E. et al. BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation. Mol Cell. 2021
- Tamburri S. et al. Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression. Mol Cell. 2020
- Lavarone et al. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. Nat Commun. 2019
- Pivetti et al. Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell-type dependent outcome. Sci Adv. 2019
- Scelfo et al. Functional Landscape of PCGF Proteins Reveals Both RING1A/B Dependent and Independent Specific Activities. Mol Cell. 2019
- Chiacchiera et al. PRC2 preserves intestinal progenitors and restricts secretory lineage commitment. EMBO J. 2016
- Chiacchiera et al. Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/ß Catenin Transcriptional Activity. Cell Stem Cell. 2016
- Ferrari et al. Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. Mol Cell. 2014
- Piunti et al. Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication. Nat Commun. 2014
- Vella et al. Tet proteins connect the O-linked Nacetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell. 2013
Full publication list (PubMed): https://www.ncbi.nlm.nih.gov/pubmed/?term=Diego+Pasini