A postdoctoral fellowship is available from September 2020 in the Unit of Gynecological Oncology Research, directed by Ugo Cavallaro, within the Department of Experimental Oncology at the European Institute of Oncology, IFOM-IEO Campus, Milan, Italy, to study the molecular and functional properties of ovarian cancer stem cells (OCSC). The postdoc will profit from unique experimental resources and leading expertise on human ovarian cancer modeling (Lupia et al, Stem Cell Reports 2018; Francavilla et al, Cell Reports 2017; Lupia and Cavallaro, Molecular Cancer 2017; Zecchini et al, EMBO Mol Med 2011). Further info on research activities of the group is available at https://www.research.ieo.it/research-and-technology/principal-investigators/unit-of-gynecological-oncology-research/.
The project, supported by AIRC (the Italian Association for Cancer Research), aims at defining novel molecular mechanisms involved in the pro-malignant function of OCSC (including ovarian cancer metastasis, recurrence and drug resistance), with the ultimate goal of identifying new therapeutic strategies. To this purpose, the postdoc will capitalize on a broad spectrum of experimental models (patient-derived primary cells, new-generation organotypic cultures, mouse xenografts) to investigate novel players and pathways involved in OCSC function. The research will profit from our close interaction with the Division of Gynecology and, hence, from the opportunity to investigate patient-specific models of outstanding clinical relevance.
We are looking for a highly motivated scientist willing to apply a wide range of cutting-edge cell and molecular biology techniques, including single-cell analysis, as well as mouse models of tumorigenesis, including patient-derived xenografts, to define the molecular traits and the functional properties of ovarian cancer stem cells.
Requirements: PhD in Molecular Biology, Cancer Biology or other related disciplines; strong motivation and research commitment; excellent analytical and organization skills; ability to work in team conjugated with independence and self-organization.
A solid background in molecular and cellular biology is essential, along with previous experience with mouse models.
Competitive salaries will depend on the candidate’s track record and experience.
The operating language of the Campus is English.
The position is for one year renewable up to three years.