The Cancer Epigenetics Laboratory investigates non-genetic alterations promoting cancer development, with a particular focus on chromatin-based mechanisms operating in solid cancers. Recent studies by our group have uncovered unexpected disease mechanisms, with direct implications for disease management (Torres et al., Science 2016, Loukas et al., Cancer Cell, 2023, Monserrat et al. Nature Cell Biology 2021, Morales et al. Nature Communications 2020). Our research combines genomics, CRISPR-based genetics, microscopy and in vivo/ex vivo functional assays to uncover new biology through the study of altered cellular states in cancer, as well as to identify associated vulnerabilities that can be exploited to interfere with the disease.
The group is currently operating across two sites, in Milan at the Department of Experimental Oncology at IEO Scaffidi Lab (IEO) and at the Francis Crick Institute in London, UK Scaffidi Lab (Crick).
We are looking for an experienced senior scientist to join the group at IEO. The successful candidate will work closely with the laboratory head to facilitate the lab transition and ensure research continuity. The appointed scientist will be expected to become a critical member of the group, who will play a lead role in the day-to-day running of the lab and help training junior members. In agreement with the PI, s/he will have the possibility to develop an ambitious line of researchaimed at dissecting epigenetic mechanisms promoting cancer development.
Key experience and competencies:
Essential
- PhD in molecular and/or cellular biology, biochemistry, or related disciplines (Master degree with excellent track record may be considered).
- Experience with chromatin biology and genomics approaches, and/or cancer biology
- Strong expertise in cell culture (transfection, transduction and clone isolation), molecular biology, biochemistry and quantitative microscopy
- Track record of writing papers as evidenced by publications, with a least one first-author publication
- Excellent spoken and written English
- Highly efficient, self-motivated, organised and effective at problem solving.
- Work independently and have a strong ability to multi-task and prioritize day-to-day tasks.
- Adaptable and willing to learn new skills, concepts and scientific techniques.
- Able to work effectively as part of a diverse team and contribute to a positive work environment.
Desirable
- Expertise with mouse models of cancer is highly desirable
- Expertise in CRISPR technology, including targeted genome editing and NGS-based selection screens
- Experience with bioinformatic analysis or mining public databases
Duration and salary: The position is initially for 3 years, with the prospect of a long-term contract.
A competitive salary, including benefits, will be offered depending on experience and qualifications. Applicants currently living abroad may be eligible for generous tax benefits upon relocation.
The Institute: The European Institute of Oncology (IEO) is one of the leading research institutes in Italy. The Department of Experimental Oncology (DEO) hosts ~250 scientists working in 20 independent research groups, and is equipped with state-of-the-art Technology Units. DEO is located within a scientific campus together with two other partner institutions: the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT). The IEO is one of the 13 members of the EU-LIFE alliance to promote excellence in life sciences in Europe. IEO is an equal opportunity employer committed to excellence through diversity.
Please apply by submitting a letter of interest and a CV.
Posted on 30th August 2023