My areas of interest focus on host-microbes interactions and the molecular mechanisms underlying the evolution and adaptation of the human gut microbiota in health and disease. Meta'omics had a huge impact on microbiome research revealing the fundamental role of intestinal microbial communities in host physiology and immune system homeostasis. My aim is to use an interdisciplinary approach exploiting all the meta'omics, immunology, in vivo models and computational biology in order to reduce the lack of knowledge concerning host-microbes interactions and crosstalk with the immune system. These new insights will lay the basis for the development of next-generation biotherapeutic approaches and innovative intervention strategies to address currently unmet medical needs.
Most Relevant Publications
Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7−/− mice.
Sci Rep, 2019
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens.
Nat Commun, 2019