I obtained the Master’s degree magna cum laude in Biological Sciences at University of Calabria in December 2009. Them, I’ve started my PhD in the laboratory of Genetics at the same University, headed by Prof. Giuseppe Passarino, working in the pioneering field of mitochondrial DNA epigenetics. I’ve got the PhD in Operative Research (bio-pathologic curriculum) in December 2012. My first postdoc experience started in April 2013 at University Magna Graecia of Catanzaro in the laboratory of molecular haematopoiesis and stem cell biology headed by the late Prof. Giovanni Morrone, studying the functional cross-talk between the zinc finger protein ZNF521 and the sonic hedgehog pathway effectors Gli1/2. In 2014, I spent one year at DKFZ in Heidelberg as visitor postdoc at the Department of Molecular Genetics headed by Prof. Dr. Peter Lichter. There, I’ve carried out two projects which focused on the functional role of ZNF521 in the biology of glioblastoma stem-like cells and its interaction with the polycomb machinery to determine their stem-like phenotype. In 2015 I’ve joined the group of Dr. Ugo Cavallaro at IEO, which make my research more translational working on patient-derived samples and taking advantage from the collaboration with IEO clinicians. Currently, I’m studying the functional contribution of the adhesion molecule L1 to the pathophysiology of ovarian cancer stem cells, focusing on the related biological mechanism and on its therapeutic implications.
Most Relevant Publications
J Clin Med, 2020
Number and brightness analysis in live cells reveals that NCAM and FGF2 elicit different assembly and dynamics of FGFR1.
J Cell Sci, 2019
The Stem Cell-Associated Transcription Co-Factor, ZNF521, Interacts With GLI1 and GLI2 and Enhances the Activity of the Sonic Hedgehog Pathway.
Cell Death Dis, 2019