Only a thorough understanding and characterization of the molecular mechanisms of cell physiology can provide the tools to effectively manipulate such processes in a pathological context. A correct cell division is crucial for cell physiology of both normal and cancer cells; therefore, the characterization of the mechanisms underlying its regulation is key to provide the knowledge to generate targeted efficient treatments addressing cancer cell proliferation and hence tumor maintenance.
Identification of Cdc20 and Cdh1 as substrate specific activators of the Anaphase Promoting Complex (APC/C)
Identification of Phosphatase Cdc14 as essential for mitotic exit and CDK inactivation and characterization of the mechanisms underlying its regulation
Identification of a novel pathway essential for anaphase progression after cohesin cleavage
