Our seminars

This is the updated calendar invitation to announce our speaker (details below) and share the “save-the-date”. New date: March 27, 2026 ​** 27/03/2026 - h. 14:00 speaker: Francesca Coscia, HT Research Group Leader, Structural Biology Research Centre title: Mechanistic insights into thyroid hormone regulation host: IEO-Sigismund location: IFOM Conference Room ** https://humantechnopole.it/en/people/francesca-coscia/ Biosketch Francesca Coscia graduated in chemistry at University of Naples, where she also obtained a Master in Biostructures in 2009, working in the group of Filomena Sica on the X-ray crystal structure of an angiogenic RNases. In 2014 she obtained her PhD at the Institute of Structural biology in Grenoble (FR) under the supervision of Carlo Petosa and Guy Schoehn. Here, she developed a method to determine cryo-EM (cryo electron microscopy) structures of small proteins by genetic fusion to symmetric scaffolds. In 2015 she moved to Birkbeck college (London, UK) as a PostDoc in Elena Orlova’s group to work on Papillomavirus helicases by cryo-EM. In 2017 she joined the the group of Jan Löwe at the MRC laboratory of molecular biology. Here, using cryo-EM she determined de novo the structure of human thyroglobulin and unravelled how it forms thyroid hormones. For her work she received in 2020 the Brenner PostDoc prize for outstanding research at MRC-LMB, in 2021 The European Thyroid Association Lecture award and the Prize for the Thyroid Physiopathology from the Italian National Academy of the Lincei. In 2021 she became a PI at the Human technopole (Milan, IT), where she will further investigate the molecular mechanisms of thyroid hormone function and disease integrating cryo-EM with biochemistry, cell biology and computational methods. In 2022 she has been awarded an ERC starting grant to image thyroid biology across scales: from atoms to organoids.

March 27, 2026