Cancer epigenomics

Emerging evidence highlights the impossibility to ascribe the whole tumor heterogeneity merely to the genetic signature of tumor cells, hence making unfeasible to predict responses to existing therapies or prioritize the search for new and/or repurposed ones. Epigenetic control of cell identity is a frequent altered feature in tumor cells, making this research field progressively assuming a relevant role in cancer biology. In this field, DEO researchers have achieved important goals, unveiling the general mechanisms as well as specific targets and biomarkers exploitable from a therapeutic point of view.