We are seeking a researcher to join a project investigating the regulatory mechanisms that drive pancreatic cancer heterogeneity. Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths by 2040, due to its rising incidence, absence of effective population screening, and limited therapeutic options. Treatment failure in PDAC is largely linked to its unique biology, particularly its high degree of cellular heterogeneity. While genetic variation contributes to transcriptional heterogeneity, current evidence suggests that signals from the tumor microenvironment (TME) play a more dominant role. As a result, PDAC cell states appear to be shaped primarily by local tissue cues rather than fixed genomic alterations. This project aims to uncover the mechanisms that govern the induction and maintenance of these alternative PDAC cell states by applying a range of functional genomics approaches.
Requirements: Degree in biological sciences or equivalent
What we offer
- A stimulating environment within the IEO Comprehensive Cancer Center, on a campus shared with IFOM and IIT; member of the EU-LIFE alliance.
- Access to state-of-the-art core facilities (proteomics, genomics, imaging, bioinformatics).
- 6-months fellowship, salary commensurate with experience and qualifications.
- Professional development opportunities and an international, collaborative culture.
IEO is an equal-opportunity employer committed to diversity and inclusion.
How to apply
To apply please use the dedicated link for submission.
Posted on 8th September 2025