Temporary research Fellowship in precision medicine for glioblastoma
Ref. 2025-11-GP/55
The Laboratory of Giuliana Pelicci at the European Institute of Oncology (IEO) in Milan, Italy, is offering a temporary research fellowship to support the development of innovative and personalized therapeutic strategies for glioblastoma, the most aggressive and common malignant brain tumor.
The fellowship is immediately available, the salary will be commensurate to the experience.
Project Overview
Glioblastoma (GBM) is among the most lethal human cancers, marked by extreme heterogeneity and poor prognosis. Despite decades of research, current treatments remain largely ineffective, and patient survival rarely exceeds two years. A major barrier to clinical progress lies in the challenge of identifying robust, actionable molecular targets within such a diverse and evolving disease landscape.
To address this, our team has developed an advanced drug screening (ADS) platform that leverages patient-derived preclinical models, including both in vitro cultures and in vivo systems. This platform enables systematic evaluation of therapeutic responses and resistance mechanisms.
The ADS approach is complemented by multi-omics analyses, encompassing genomic, transcriptomic, and epigenetic profiling, to uncover the molecular determinants of GBM heterogeneity and treatment resistance.
Together, these integrated methodologies aim to accelerate the translation of personalized medicine into effective therapeutic interventions for GBM patients.
Responsibilities
The selected fellow will focus on:
- The establishment and molecular characterization of patient-derived GBM models (in vitro and in vivo);
- The application and optimization of the advanced drug screening workflow;
- The execution and interpretation of multi-omics datasets (genomic, transcriptomic, epigenetic).
Candidate Profile
We seek a motivated and team-oriented researcher with a strong background in cellular and molecular biology.
Previous experience in cancer biology, drug screening, or multi-omics approaches will be considered a significant asset.
Required:
Master Degree in Biology, Biotechnology, Biomedical Engineering, Oncology, Genetics, Pharmacology, Molecular Medicine, Chemistry or relative disciplines;
Good/excellent knowledge of the English language
Processing personal data
The personal data, compulsorily provided, will be processed in compliance with Legislative Decree no. 101 of 10 August 2018, which adapts the Personal Data Protection Code (Legislative Decree no. 196 of 30 June 2003) to the provisions of Regulation (EU) 2016/679, and only for the fulfilments related to this procedure and for those consequent to the possible establishment of the working relationship, according to what is also provided for in the privacy policy, which must be accepted by each candidate at the time of sending his/her application.
Equal opportunities
This notice is issued in compliance with equal opportunities between men and women for access to employment (L. 903/77) and economic treatment, pursuant to Legislative Decree no. 198/2006.
Posted on November 13th, 2025