We are recruiting one postdoctoral fellow to work on a project focusing on post-transcriptional control of pancreatic cancer heterogeneity. Because of its progressively increasing incidence, lack of available population screenings and limited therapeutic efficacy, PDAC will become the second cause of cancer deaths by 2040. Due to advanced disease at diagnosis, 80-85% of PDAC patients cannot undergo surgery and have a median life expectancy lower than 6 months. A large share of treatment failures is rooted in the peculiar biological properties of this cancer and specifically in its extensive cellular heterogeneity. Current data indicate that the contribution of genetic diversity to transcriptional heterogeneity in PDAC, albeit detectable, is lower than that of instructive signals generated by the tumor microenvironment (TME). Therefore, different PDAC “cell states” appear to be mainly driven by local tissue signals rather than being hardwired in cancer cell genomes. Using a combination of functional genomics technologies, the overall objective of this project is to identify post-transcriptional mechanisms that control the induction and maintenance of alternative PDAC cell states.
Requirements: PhD in Molecular/Cellular Biology, Pharmacology, Biotechnology, Biochemistry, Molecular Oncology, Systems Medicine or related fields
What we offer
- A stimulating environment within the IEO Comprehensive Cancer Center, on a campus shared with IFOM and IIT; member of the EU-LIFE alliance.
- Access to state-of-the-art core facilities (proteomics, genomics, imaging, bioinformatics).
- 6-months fellowship, salary commensurate with experience and qualifications.
- Professional development opportunities and an international, collaborative culture.
IEO is an equal-opportunity employer committed to diversity and inclusion.
How to apply
To apply please use the dedicated link for submission.
Posted on 8th September 2025