Start date: 1 year fellowship, renewable based on progress and funding.
About the lab
The laboratory of Dr. Tiziana Bonaldi investigates how epigenetic enzymes—with a focus on protein methyltransferases and demethylases—shape cancer cell heterogeneity, plasticity and treatment response. We integrate mass-spectrometry (MS)-based proteomics (including histone PTMs/epiproteomics) with epigenomics, transcriptomics and metabolomics, coupled to pharmacological and genetic perturbations, primarily in breast and ovarian cancer models.
Project
Within an AIRC-IG 2023–funded, multidisciplinary program, the postdoc will dissect the functional and mechanistic role of epigenetic enzymes in ovarian-cancer chemoresistance across transcriptional, translational and metabolic layers. The project scope can be tailored to the candidate’s expertise following discussion with the PI.
Responsibilities
- Design and execute experiments in cellular models (2D/3D; organotypic as applicable).
- Apply and/or coordinate MS-based proteomics/epiproteomics and integrate with epigenomic and RNA/miRNA sequencing datasets.
- Analyze and interpret multi-omics data, in collaboration with bioinformatics partners.
- Document results, present within and outside the institute, and contribute to manuscript and grant preparation.
- Support collaborations within the campus and external partners.
Qualifications
- PhD in Molecular/Cellular Biology, Biotechnology, Biochemistry, Molecular Oncology, Systems Medicine or related fields.
- Strong hands-on experience in biochemistry and cell/molecular biology; familiarity with epigenomic assays is an advantage.
- Experience with LC-MS/MS proteomics (sample prep, acquisition, data analysis) is a strong plus.
- Excellent written and spoken English; clear scientific communication and teamwork skills.
- High reliability, precision, and commitment to rigorous, reproducible research.
What we offer
- A stimulating environment within the IEO Comprehensive Cancer Center, on a campus shared with IFOM and IIT; member of the EU-LIFE alliance.
- Access to state-of-the-art core facilities (proteomics, genomics, imaging, bioinformatics).
- Salary commensurate with experience and qualifications.
- Professional development opportunities and an international, collaborative culture.
IEO is an equal-opportunity employer committed to diversity and inclusion.
How to apply
To apply please use the dedicated link for submission.
Posted on 8th September 2025