A Post-Doctoral position is immediately available in Nuclear Proteomics and Gene expression regulation laboratory of Dr. Tiziana Bonaldi at the Department of Experimental Oncology of the European Institute of Oncology (IEO) IRCCS in Milano.
Our research focuses on integrating multiple MS-based proteomics approaches to characterize the contribution of epigenetic enzymes (with a special focus on protein methyl-transferases and demethylases) in defining heterogeneity, plasticity, and response to treatment and in cancer, with a focus on breast and ovarian cancer.
Within a multi-disciplinary project whereby MS-based profiling of post-translational modifications is coupled with epigenomics and transcriptomics analyses, together with the pharmacological and genetic modulation of epigenetic enzymes, we are seeking for a highly motivated post-doctoral applicant, who will contribute to the functional and mechanistic investigation of the role of epigenetic enzymes in ovarian cancer chemo-resistance, at the transcriptional, translational and metabolic level.
The fellowship is up to 3 years, with possibility of further extension, on the basis of project progression. The project can be tailored, within the framework of a 5-years AIRC-IG 2023 grant just started, based on the candidate’s expertise and vision, upon in-depth discussion with the PI.
The annual salary will be defined based on the seniority and expertise of the candidate.
Requisites of the candidate:
- PhD degree in Molecular and Cellular Biology, Biotechnology, Biochemistry, Molecular Oncology, Systems Medicine or related disciplines;
- Expertise in biochemistry and cellular biology techniques;
- Strong experience in biochemistry and molecular biology, including genome editing.
- Expertise in Mass Spectrometry/Proteomics will be considered a plus
- Good knowledge of the English language;
- Reliability, precision; strong commitment to science
- Excellent communication skills and strong attitude toward team work.
The European Institute of Oncology is one of Europe’s most influential cancer research institutes. The IEO operates as a Comprehensive Cancer Center, linking fundamental and applied research to clinical activities, patient care and clinical trials. The department of Experimental Oncology (DEO) is currently composed of ~250 scientists working in 15 independent research groups and units. DEO is located within a scientific campus together with two other partner institutions: the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT). The IEO is one of the 13 members of the EU-LIFE alliance to promote excellence in life sciences in Europe. The operating language of the lab is English.
IEO is an equal opportunity employer, committed to excellence through diversity.
Posted on 30th January 2024