Postdoctoral researcher. Wnt self-renewal (Ref.2025-07-MM/29)

 

We are looking for a candidate with a strong background in structural biology, with particular interest in Cryo-Electron Microscopy techniques and good experience in biochemistry of large macromolecular assemblies. Candidates with skills in proteomics, genomics or organoid biology are also encouraged to apply.

 

The project will explore fundamental questions on mechanisms of cell proliferation, stem cell self-renewal, and fate decision. To gain molecular information, research in our lab integrates integrative structural biology with proteomics, genomics and cell biology of intestinal cells. Experimental approaches such as biochemistry, structural biology, and cell biology are well established in the lab (Palmerini, Nat. Comm. 2021, Pirovano, Nat. Comm. 2019; Culurgioni & Mari, Nat. Comm. 2018; Carminati, NSMB 2016; Gallini, Curr. Biol. 2016), and additional techniques of stem cell manipulation and imaging in intestinal organoids have been developed more recently.

 

For more information about the lab please visit: https://www.research.ieo.it/research-and-technology/principal-investigators/marina-mapelli/

 

The recruited Postdoctoral fellow will be integrated in the Mapelli lab, at the IEO Department of Experimental Oncology based at the IFOM-IEO Campus (Milan, IT), which provides an excellent environment at the interface between structural biology, cell biology and cancer genetics. The working language in the lab is English. The researchers will receive a salary and health/social security coverage from the IEO. The contract will be initially for one or two years, with possible extensions until the end of the project. The starting date is negotiable.