Patents
Therapeutic Small Molecules
Epigenetic drugs for the treatment of viral infections
New potential therapeutics for SARS-CoV-2-infected patients
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Therapeutic strategy against cancer escaping metabolic inhibitors
New anti-cancer metabolic therapy based on PP2A activator molecules
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Histone demethylases to ameliorate core symptoms in rare subtypes of Autism Spectrum Disorder
Novel pharmacological agents for the treatment of core symptoms of rare subtypes of Autism Spectrum Disorders
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iRASP: a novel platform to design efficacious cancer targeted immunotherapies
New therapeutic antibodies for the treatment of intractable tumors
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Unlocking adoptive cell therapy by lipid-mediated metabolic reprogramming
A novel strategy based on the use of specific types of lipids to boost Adoptive Cell Therapy efficacy for the treatment of a broader range of human malignancies, including solid tumors
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L1-ΔTM: New circulating biomarker of tumor angiogenesis
Novel biomarker for the non-invasive diagnosis and therapeutic monitoring of cancer patients
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Monoclonal Antibodies
| Target protein | Clone(s) | Applications | Reactivity | Group leader | References | Supplier |
| Cmt2 | E29-19-14 | WB, IF, IP |
| Andrea Musacchio |
| EMD Millipore |
| DEPDC1B (DEP domain-containing protein 1B) | CH18-2-9 | WB, IP | human, mouse | Pier Paolo Di Fiore |
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| DLG1 (Disks large homolog 1) | B7-1 | IF | Human | Pier Giuseppe Pelicci |
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| Dsn1 | RD36-1 | WB, IF, IP | Human | Andrea Musacchio |
| EMD Millipore |
| NP95 (E3 ubiquitin-protein ligase UHRF1) | BF18-11 | WB, IP, IF | mouse | Pier Paolo Di Fiore |
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| EPS15 (Epidermal growth factor receptor substrate 15) | 15-3T | WB, IP, IF | human, mouse | Pier Paolo Di Fiore |
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| HDAC1 pSer406 | BT-15 | IF, WB, IP | Human, Zebrafish, Mouse | Susanna Chiocca | Segrè CV et al., MAbs 2015 | EMD Millipore; Biolegend |
| Mad1 (mitotic arrest deficient 2) | BB3-8 | WB, IF, IP | Human | Andrea Musacchio | Screpanti E et al., Curr Biol. 2011; Santaguida S et al., J Cell Biol 2010; De Antoni A et al., Curr Biol 2005; Steensgaard et al., EMBO Rep 2004; DeLuca et al., Curr Biol 2003 | EMD Millipore |
| Mad2 (mitotic arrest deficient 2) | AS55-A12 | WB, IF, IP | Human | Andrea Musacchio | Screpanti E et al., Curr Biol. 2011; Santaguida S et al., J Cell Biol 2010; De Antoni A et al., Curr Biol 2005; Steensgaard et al., EMBO Rep 2004; DeLuca et al., Curr Biol 2003 | EMD Millipore |
| Notch1 (Neurogenic locus notch homolog protein 1) | BB25-15-2; 18G12-1 | WB | Human | Pier Paolo Di Fiore |
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| NUDCD1 (NudC domain-containing protein 1) | AR55-1-4 | WB, IF, IP, IHC paraffin | human | Pier Paolo Di Fiore |
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| NuMA1 (Nuclear mitotic apparatus protein 1) | AD6-1 | IF,WB | Human, mouse | Marina Mapelli | Gallini S et al., Current Biology 2016; Carminati M et al., NSMB 2016; Pirovano L et al., Nat. Comm 2019 | EMD Millipore |
| NUMB (Protein numb homolog) | AB21-39-25-15; AA19-2; AP35-A1 | WB, IHC, IF | human, mouse | Pier Paolo Di Fiore | Colaluca I et al., Nature 2008 |
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| p66shc | BG8-SU1 | WB, IP, IF | human, mouse | Pier Giuseppe Pelicci | Orsini et al., JBC 2004 |
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| Protein FAM91A1 | BL5-4; EI1-3; P1-84; P1-65 | WB, IP, IF, IHC paraffin | human, mouse | Pier Paolo Di Fiore | Nicassio F et al., J Clin Invest 2005 |
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| RAI (SHC C) | IF15-E2 | IHC, WB, IP | human, mouse | Giuliana Pelicci | Villanacci V et al., Neurogastroenterol Motil 2008 | EMD Millipore |
| RaLP (RAI-like protein) | AW47-10-21; AW47-10-5; AI22-20-8; AI22-20-15 | WB | human, mouse | Luisa Lanfrancone |
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| RN-tre | 15-6-11; 15-B | WB, IP, IF | human | Pier Paolo Di Fiore | Lanzetti L et al., Nature 2004 |
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| SCC-112 (Sister chromatid cohesion protein PDS5 homolog A) | AF5-21-7 | WB, IP, IF, IHC paraffin | human, mouse | Pier Paolo Di Fiore |
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| SMU1 (WD40 repeat-containing protein SMU1) | AQ26-ED8-22-11 | WB, IF, IHC paraffin | human | Pier Paolo Di Fiore |
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| USP3 (Ubiquitin carboxyl-terminal hydrolase 3) | AE9-12-1 | WB, IP | human, mouse | Pier Paolo Di Fiore | Nicassio F et al; Curr Biol 2007 |
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