Partnering Opportunities

Patents

Therapeutic Small Molecules

 

Epigenetic drugs for the treatment of viral infections

New potential therapeutics for SARS-CoV-2-infected patients

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Therapeutic strategy against cancer escaping metabolic inhibitors

New anti-cancer metabolic therapy based on PP2A activator molecules

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Histone demethylases to ameliorate core symptoms in rare subtypes of Autism Spectrum Disorder

Novel pharmacological agents for the treatment of core symptoms of rare subtypes of Autism Spectrum Disorders

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Repositioning of histone deacetylase inhibitors to treat core symptoms of Autism Spectrum Disorder

Histone deacetylase for the treatment of core symptoms of rare subtype of Autism Spectrum Disorder 

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Biologicals

 

iRASP: a novel platform to design efficacious cancer targeted immunotherapies

New therapeutic antibodies for the treatment of intractable tumors

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Methods and biomarkers

 

L1-ΔTM: New circulating biomarker of tumor angiogenesis

Novel biomarker for the non-invasive diagnosis and therapeutic monitoring of cancer patients

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Research tools

Monoclonal Antibodies

Target protein

Clone(s)

Applications

Reactivity

Group leader

References

Supplier

Cmt2

E29-19-14

WB, IF, IP

 

Andrea Musacchio

 

EMD Millipore

DEPDC1B (DEP domain-containing protein 1B)

CH18-2-9

WB, IP

human, mouse

Pier Paolo Di Fiore

 

 

DLG1 (Disks large homolog 1)

B7-1

IF

Human

Pier Giuseppe Pelicci

 

 

Dsn1

RD36-1

WB, IF, IP

Human

Andrea Musacchio

 

EMD Millipore

NP95 (E3 ubiquitin-protein ligase UHRF1)

BF18-11

WB, IP, IF

mouse

Pier Paolo Di Fiore

 

 

EPS15 (Epidermal growth factor receptor substrate 15)

15-3T

WB, IP, IF

human, mouse

Pier Paolo Di Fiore

 

 

HDAC1 pSer406

BT-15 

IF, WB, IP

Human, Zebrafish, Mouse

Susanna Chiocca

Segrè CV et al., MAbs 2015

EMD Millipore; Biolegend

Mad1 (mitotic arrest deficient 2)

BB3-8

WB, IF, IP

Human

Andrea Musacchio

Screpanti E et al.,  Curr Biol. 2011;  Santaguida S et al., J Cell Biol 2010; De Antoni A et al., Curr Biol 2005; Steensgaard et al., EMBO Rep 2004; DeLuca et al., Curr Biol 2003

EMD Millipore

Mad2 (mitotic arrest deficient 2)

AS55-A12

WB, IF, IP

Human

Andrea Musacchio

Screpanti E et al.,  Curr Biol. 2011;  Santaguida S et al., J Cell Biol 2010; De Antoni A et al., Curr Biol 2005; Steensgaard et al., EMBO Rep 2004; DeLuca et al., Curr Biol 2003

EMD Millipore

Notch1 (Neurogenic locus notch homolog protein 1)

BB25-15-2; 18G12-1

WB

Human

Pier Paolo Di Fiore

 

 

NUDCD1 (NudC domain-containing protein 1)

AR55-1-4

WB, IF, IP, IHC paraffin

human

Pier Paolo Di Fiore

 

 

NuMA1 (Nuclear mitotic apparatus protein 1)

AD6-1

IF,WB

Human, mouse

Marina Mapelli

Gallini S et al., Current Biology 2016;  Carminati M et al., NSMB 2016;  Pirovano L et al., Nat. Comm 2019

EMD Millipore

NUMB (Protein numb homolog)

AB21-39-25-15; AA19-2; AP35-A1

WB, IHC, IF

human, mouse

Pier Paolo Di Fiore

Colaluca I et al., Nature 2008

 

p66shc

BG8-SU1

WB, IP, IF

human, mouse

Pier Giuseppe Pelicci

Orsini et al., JBC 2004 

 

Protein FAM91A1

BL5-4; EI1-3; P1-84; P1-65

WB, IP, IF,  IHC paraffin

human, mouse

Pier Paolo Di Fiore

Nicassio F et al., J Clin Invest 2005

 

RAI (SHC C)

IF15-E2

IHC, WB, IP

human, mouse

Giuliana Pelicci

 Villanacci V et al., Neurogastroenterol Motil 2008

 EMD Millipore

RaLP (RAI-like protein)

AW47-10-21; AW47-10-5; AI22-20-8; AI22-20-15

WB

human, mouse

Luisa Lanfrancone

 

 

RN-tre

15-6-11; 15-B

WB, IP, IF

human

Pier Paolo Di Fiore

Lanzetti L et al., Nature 2004

 

SCC-112 (Sister chromatid cohesion protein PDS5 homolog A)

AF5-21-7

WB, IP, IF, IHC paraffin

human, mouse

Pier Paolo Di Fiore

 

 

SMU1 (WD40 repeat-containing protein SMU1)

AQ26-ED8-22-11

WB, IF, IHC paraffin

human

Pier Paolo Di Fiore

 

 

USP3 (Ubiquitin carboxyl-terminal hydrolase 3)

AE9-12-1

WB, IP

human, mouse

Pier Paolo Di Fiore

Nicassio F et al;  Curr Biol 2007

 

For more information please contact IEO-TT

Download IEO Mabs Catalogue

Preclinical models

Please contact IEO-TT

Research programs

Please contact IEO-TT

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