Molecular Mechanisms of Cancer and Aging
|Telephone||+39 02 57489831|
|Location|| Building 13 |
Via Adamello 16, Milano
Our group has traditionally focused on the elucidation of molecular and biological mechanisms of tumorigenesis, focusing on myeloid leukemia and breast cancer. We have i) identified and characterized several AML-associated genetic alterations (PML-RARa; NPMc+); ii) defined biological mechanisms of tumorigenesis (for example their effect on chromatin) and iii) exploited our findings for the development of novel targeted treatments (retinoic acid, HDAC inhibitors, Lysine demethylase inhibitors). Furthermore, we have defined the underlying molecular (p53 and p21) and biological (symmetric vs asymmetric division) mechanisms contributing to CSC pool maintenance.
More recently, our group has been focusing on the analysis of intratumor heterogeneity, particularly on the study of adaptive responses, with the aim of defining its role during tumor progression and treatment resistance.
Major emphasis is given to explore mechanisms of accumulation of DNA damage in cancer cells.
A parallel line of investigation focuses on the role of the aging gene p66, which we discovered in 1999 as being involved in the regulation of oxidative stress response.
Most Relevant Publications
Obesity Is A Risk Factor For Acute Promyelocytic Leukemia: Evidence From Population And Cross-Sectional Studies Studies And Correlation With Flt3 Mutations And Polyunsaturated Fatty Acid Metabolism.
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
Nat Genet., 2019
p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value.
Cell Rep., 2019