Technological Units

Screening Unit

Giuseppina Giardina

Giuseppina Giardina

Unit Coordinator

Telephone +390294375000
Location Building 13
Floor 1st
Via Adamello 16, Milano

The Screening Unit (SU) aims to provide open access for academic projects towards experiments in medium-throughput fashion. The Screening Unit serves for systematic, plate-based screenings of cellular and biochemical assays, with collections of chemical libraries with state-of-the-art equipment.


The mission of the Screening Unit is to:

  • Provide screening collections of compound libraries.
  • Identify bioactive compounds capable of modulating cellular functions.
  • Miniaturize test volumes to reduce costs for expensive reagents.


The SU staff provides general steps of medium-throughput screening:

  • Preparation of cells and compounds libraries.
  • Small scale test with positive and negative controls to test Dimethyl sulfoxide (DMSO tolerance) on a given target cell.
  • Pilot screen with a small number of already used compounds to test different readouts, positional effects of plates and systematic liquid handling errors.
  • Configuration and programming of the Tecan Freedon evo robot.
  • Data acquisition and handling from automatic plate reader.
  • Validation of identified effective compounds.
  • Access to the unit to carry out screens upon appropriate training.
  • Problem solving.


The SU hosts an open access technology platform of:

  • Tecan Freedon evo robot.
  • Automatic plate readers (Infinite 200 Tecan, GLOMAX Explorer Promega and PHERAstar BMG LABTECH).

Most Relevant Publications


Mirko Doni

Screening Unit User Group

Our site uses cookies for better browsing usability and statistics on its use. If you want to learn more, or refuse consent to all or some cookies, click here.