The lab of Mechanistic basis of self-renewal headed by Marina Mapelli is looking for two post-graduate experimental scientists to work on Wnt-dependent self-renewal in the regulation of stem cell activity, tissue homeostasis and oncogenesis using a combination of cutting-edge technologies including structural biology (cryo-EM), biochemistry, advanced quantitative imaging in cells and intestinal organoids as well as multi-omics. The positions involve tight interactions with other members of a team working on different aspects of Wnt self-renewal. The Mapelli Lab is based at the Department of Experimental Oncology of the European Institute of Oncology, close to the city center of Milan, which offers opportunities for a lively cultural life and nearby outdoor activities.
Qualifications: Applicants should hold a degree in life sciences, medical engineering or related disciplines, and show experience in biochemistry and structural biology (position-1) or molecular and cell biology (position-2).
Key requirements: We are looking for highly motivated research scientists driven by scientific curiosity, with a strong attitude to develop their research projects. Proficient English, excellent organizational and collaborative skills as well as enthusiasm for science and research are essential.
Ph.D. training: Post-graduate students will be encouraged to apply at the selection of the European School of Molecular Medicine SEMM (www.semm.it) in July 2023 to join our Ph.D. program.
Institution: The European Institute of Oncology is a comprehensive Cancer Center, linking basic and translational research to clinical activities. The Department of Experimental Oncology hosts about 250 researchers working in 20 independent groups. It is located in a scientific Campus together with the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT), and benefits from state-of-the-art Technological Units. IEO belongs to the EU-LIFE alliance for the promotion of science excellence in Europe. IEO is an equal opportunity employer committed to excellence through diversity.
How to apply: Applicants are encouraged to contact Marina Mapelli as early as possible, sending a brief description of interests, a CV, and contact information of references to [email protected].
Selected publications
- Lechler T, Mapelli M. Spindle positioning and its impact on vertebrate tissue architecture and cell fate. Nat Rev Mol Cell Biol, 2021
- Palmerini V et al. Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions. Nat Comm, 2021
- Pirovano L et al. Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions. Nat Comm, 2019
- Culurgioni S et al. Insc:LGN tetramers promote asymmetric divisions of mammary stem cells. Nat Comm, 2018
Useful Links:
Mapelli Lab: https://www.ieo.it/en/RESEARCH/People/Researchers/Mapelli-Marina/
IEO-Research: https://www.research.ieo.it/