Irene graduated with a degree in Biology from the University of Naples “Federico II” in 2013. Her undergraduate and master’s thesis projects were performed in Prof. Girolama La Mantia’s group and were focused on the characterization of the role of the DNp63a isoform and the oncoprotein YB-1 in the control of proliferation and differentiation of keratinocytes (Troiano et al. 2015). It was during this experience that she became interested in cancer research. After graduation, she spent six months at the Children’s Hospital of Philadelphia (USA) in the lab of Dr. Mason and Dr. Bessler, where she studied somatic mutations in patients with bone marrow failure syndromes (Perdigones et al. 2016). This experience reinforced her interest in research and prompted her to apply for a PhD in Molecular Oncology at the European School of Molecular Medicine (SEMM). Her PhD, performed in Prof. Pier Paolo Di Fiore’s group at the FIRC Institute for Molecular Oncology (IFOM) in Milan, was focused on the functional characterization of the endocytic protein, Epsin3 and its role in breast cancer. After completing her PhD in 2019, Irene took the position of post-doc in Prof. Di Fiore’s group at the Istituto Europeo di Oncologia (IEO), funded by a 3-year AIRC Fellowship. Her work has contributed to the identification of the molecular mechanisms underlying the oncogenic properties of Epsin3, involving EMT and the regulation of the mammary stem cell compartment (Shiano Lomoriello et al. 2020).
Most Relevant Publications
A Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic Behavior.
Nat Commun, 2020
Am J Hematolog, 2016
Y-box Binding Protein-1 Is Part of a Complex Molecular Network Linking ΔNp63α to the PI3K/akt Pathway in Cutaneous Squamous Cell Carcinoma
J Cell Physiol, 2015