|Location|| Building 13 |
Via Adamello 16, Milano
I was born in Santiago (Chile) and raised in an international environment. I obtained a Medical Degree (1985) and a Ph.D. in Hematology (1990) at the University of Perugia. After two years in the Human Genetics Lab in the IIGB in Naples, I returned to the Molecular Biology Laboratory headed by Pier Giuseppe Pelicci in Perugia. In 1995 I joined the Department of Experimental Oncology of IEO.
I have been actively involved in the study of the molecular defects underlying acute myeloid leukemia (AML) since 1987. Major achievements include: cloning of the 15;17 translocation of acute promyelocytic leukemia, functional analysis of the PML/RAR fusion protein, analysis of transcriptional regulation associated to expression of the leukemogenic fusion proteins PML/RAR, PLZF/RAR and AML1/ETO, identification of mutations in the nucleophosmin (NPM1) gene in AML patients with normal karyotype, identification of a specific expression profile associated to AML with NPM1 mutations, analysis of AML1/ETO genomic binding pattern and identification of the cell-cycle inhibitor p21 as a crucial player in the maintenance of self-renewal of leukemia stem cells. I developed a solid experience in the use of functional and genomic approaches and focused much of my recent interest on exploiting an integrated genomic approach to study the molecular basis of human diseases.
I am full professor of Medical Genetics at the University of Milan and Deputy Scientific Coordinator of Alliance Against Cancer.
Most Relevant Publications
Wnt Signalling in Acute Myeloid Leukaemia.
Adhesion Deregulation in Acute Myeloid Leukaemia.
Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development.
AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells.
Sci Rep, 2016