Translational oncology
Luca Mazzarella
Clinician Scientist
[email protected] | |
Telephone | +39 02 94375111 |
Location | Building 13 Floor 2nd Via Adamello 16, Milano |
We believe that cancer can be understood and managed only by a multi-layered approach where methods originating from multiple disciplines are integrated. These include laboratory techniques, high-throughput sequencing, clinical trial design, social sciences, with a heavy reliance on computational analyses.
We are creating a group of enthusiastic people with variegated backgrounds to foster cross-fertilization from different branches of knowledge, to provide comprehensive answers to clinically and biologically relevant questions. We participate in several collaborations within IEO and national and international groups.
Areas of specific interest:
- Metabolism and cancer. We study molecular mechanisms mediating the effect of diet on cancer, in particular on cancer stem cells and the immune environment.
- Chromatin modifiers as therapeutic targets in cancer and immunity. We study the role of histone modifications in hematopoietic and immune cells, and how they can be pharmacologically targeted for modulating the immune response.
- Cancer genomics and biomarker discovery. We perform translational studies in clinical trials to identify biomarkers for response prediction, diagnosis and genetic risk.
- Bioinformatic tools for clinical genomics. We develop tools for the management of sequencing data for clinical trial design and diagnosis.
- Quantitative social studies applied to medicine, in particular on privacy, health economics and accessibility to clinical trials
Most Relevant Publications
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Di Chiaro P, Nacci L, Arco F, Brandini S, Polletti S, Palamidessi A, Donati B, Soriani C, Gualdrini F, Frigè G, Mazzarella L, Ciarrocchi A, Zerbi A, Spaggiari P, Scita G, Rodighiero S, Barozzi I, Diaferia GR, Natoli G
Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.
Cancer Cell, 2024
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Casolino R, Beer PA, Chakravarty D, Davis MB, Malapelle U, Mazzarella L, Normanno N, Pauli C, Subbiah V, Turnbull C, Westphalen CB, Biankin AV
Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance.
CA Cancer J Clin, 2024
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Pallavi R, Gatti E, Durfort T, Stendardo M, Ravasio R, Leonardi T, Falvo P, Duso BA, Punzi S, Xieraili A, Polazzi A, Verrelli D, Trastulli D, Ronzoni S, Frascolla S, Perticari G, Elgendy M, Varasi M, Colombo E, Giorgio M, Lanfrancone L, Minucci S, Mazzarella L, Pelicci PG
Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion.
Nat Commun, 2024