Alleanza Contro il Cancro (ACC)

Alleanza Contro il Cancro (ACC), a consortium of 27 cancer centres across Italy. The PI coordinates the ACC Genomics Working Group. The ACC projects include:

  • The ACC lung pilot project, sequencing 1000 lung cancer actionable genomes with a custom targeted sequencing panel.
  • The ACC GerSom project, sequencing 4500 cases of breast, ovarian and colorectal cancer with a large panel including actionable, driver and risk-associated genes.
  • OncNGS, a European effort to build a novel comprehensive liquid biopsy test.


  • The PERSONA breast/ovary trials, to map cancer risk-associated genes in unsorted triple negative breast and ovarian cancer. Ancillary pojects explore radiomics and psychosocial matters.
  • The IEO838 trial, exploring biomarkers of response to neoadjuvant dual immune checkpoint blockade in locally advanced melanoma.

University of Pavia (E Rumi)

Genetic basis of triple-negative and familial myeloproliferative neoplasms.

Institut Curie, Paris (C Le Tourneau)

PEVO trial on epigenetic + immunological therapy on squamous cancers.

Ludwig Cancer Centre, Lausanne (C Jandus)

Role of innate lymphoid cells in cancer.

Social studies

  • With Chiara Demartini (UniPv) and Fabio Pammolli (PoliMi) on health economics of precision medicine.
  • With Ketti Mazzocco (IEO) for patients' decision-making in cancer risk management.

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