Translational Research Programs

Novel Diagnostics Program

Pier Paolo Di Fiore

Pier Paolo Di Fiore

Director

Email pierpaolo.difiore@ieo.it
Telephone + 39 02 94375198
Location Building 13
Floor 3rd
Via Adamello 16, Milano

The application of ‘omics’ technologies to cancer has revealed the full extent of the molecular heterogeneity of this disease and brought into question the ‘one-size-fits-all’ approach to therapy. Our challenge now is to exploit the wealth of molecular knowledge stemming from ‘omics’ projects, to develop innovative clinical tools for the personalized management of cancer. The Novel Diagnostics Program strives to do just this through projects aimed at mining profiles generated in the lab to identify and, eventually, validate novel tumor markers for the diagnosis, prognosis, stratification, and therapy response prediction in cancer patients.The program is equipped with cutting-edge technological platforms and experienced research staff dedicated to the screening and clinical validation of candidate markers in large patient cohorts, statistical analyses to develop cancer risk models, validation studies in pre-clinical models, and assay optimization to increase transferability to the clinic. Close ties between the Program and the IEO clinical divisions ensure that the Program addresses the most pressing unmet clinical needs, and also facilitate the clinical development of novel tests by allowing access to patient cohorts and the setup of clinical trials.

Current activities of the Novel Diagnostics Program are focused on the identification and validation of biomarkers for diagnostic, prognostic and therapeutic stratification in breast, prostate, bladder and lung cancers, with a special focus on the characterization and clinical validation of biomarkers based on the biology of cancer stem cells.

Most Relevant Publications

Deputy Director

Salvatore Pece

Group Scientist

Francesca Montani

Program Manager

Bronislava Matoskova

Pathologist

Giovanni Bertalot

Postdoc

Micol Tillhon

Scientific Writer

Rosalind Helen Gunby

PhD Student

Andrea Castiglioni

Fellow

Stefano Capoano

Novel Diagnostics activities

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