Biochemistry and Structural Biology Unit

Luigi Scietti
Unit Coordinator
[email protected] | |
Location |
Building 13
Floor 3rd Via Adamello 16, Milano |
The Biochemistry and Structural Biology Unit (BSU) provides high-quality technical support, training, equipment and services in recombinant protein production, biochemistry, protein biophysics and structural biology (X-ray crystallography and CryoEM).
From expression to structure determination, we deliver comprehensive solutions for protein science and structural biology aimed at the understanding of cellular processes at the atomic detail.

Most Relevant Publications
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Rinaldi F, Schipani F, Balboni B, Catalano F, Marotta R, Myers SH, Previtali V, Veronesi M, Scietti L, Cecatiello V, Pasqualato S, Ortega JA, Girotto S, Cavalli A
Isolation and characterization of monomeric human RAD51: a novel tool for investigating homologous recombination in cancer.
Angew Chem Int Ed Engl, 2023
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Pirovano L, Culurgioni S, Carminati M, Alfieri A, Monzani S, Cecatiello V, Gaddoni C, Rizzelli F, Foadi J, Pasqualato S, Mapelli M
Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.
Nat Commun, 2019
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Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A
The pseudo GTPase CENP-M drives human kinetochore assembly.
Elife, 2014
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Maspero E, Valentini E, Mari S, Cecatiello V, Soffientini P, Pasqualato S, Polo S
Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.
Nat Struct Mol Biol, 2013