Biochemistry and Structural Biology Unit
Luigi Scietti
Unit Coordinator
| [email protected] | |
| Location |
Building 13
Floor 3rd Via Adamello 16, Milano |
Almost all aspect of life are engineered at the molecular level, and without understanding molecules we can only have a sketchy understanding of life itself
Francis Crick, 1988
(What Mad Pursuit: A Personal View of Scientific Discovery)
The Biochemistry and Structural Biology Unit (BSU) at the European Institute of Oncology (IEO - Milan - Italy) provides high-quality technical support, training and equipment in recombinant protein production, biochemistry, biophysics and structural biology (X-ray crystallography and CryoEM).
The BSU works in close contact with the Principal Investigators to allow the study of the structure and function of biological macromolecules, thus enabling the molecular understanding of cellular processes.
Most Relevant Publications
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Isolation and characterization of monomeric human RAD51: a novel tool for investigating homologous recombination in cancer.
Angew Chem Int Ed Engl, 2023
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Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.
Nat Commun, 2019
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The pseudo GTPase CENP-M drives human kinetochore assembly.
Elife, 2014
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Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.
Nat Struct Mol Biol, 2013
